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KMID : 0356920100590010022
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Korean Journal of Anesthesiology
2010 Volume.59 No. 1 p.22 ~ p.26
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The effect of intravenous low dose ketamine for reducing postoperative sore throat
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Park Sun-Young
Kim Sang-Hyun
Noh Jung-Il
Lee Su-Myoung
Kim Mun-Gyu
Kim Sang-Ho
Ok Si-Young
Kim Soon-Im
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Abstract
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Background: This study was performed to evaluate the effectiveness of intravenous low dose ketamine for reducing the incidence and severity of postoperative sore throat (POST).
Methods: This was a prospective, randomized, double-blind clinical trial. The study population consisted of 70 patients between 20 and 70 years old who were classified as American Society of Anesthesiologists I-II and were scheduled for elective laparoscopic cholecystectomy. The patients were divided randomly into two groups. Patients in the ketamine group received an intravenous injection of 0.5 mg/kg of ketamine just before induction, followed by 10 μg/kg/min throughout the operation. Patients in the control group received intravenous saline instead of ketamine. The patients were interviewed 1, 6, and 24 h after the operation. The incidence and severity of POST were recorded.
Results: No significant differences in the incidence and severity of POST during the 24 h after the operation were found between the two groups (21/31 in the ketamine group vs. 26/34 in the control group, P = 0.398).
Conclusions: Intravenous injection of low dose ketamine was not effective for reducing POST.
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KEYWORD
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Complications, Intubation, Ketamine
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